September 2, 2013

Discovery of Novel Antipsychotics through Quantum Similarity

The project is supported by a Phase I SBIR grant award from the National Institute of Mental Health (1R43MH101892-01).

The experimental work will be subcontracted to the laboratory of Dr. Andrea Giuffrida, at the University of Texas Health Science Center at San Antonio.

Project Narrative:

Schizophrenia is a complex psychiatric disorder with a heterogeneous clinical phenotype. It is one of the most costly psychiatric illnesses, not only in terms of direct cost but also as a result of its long-term impact and loss of productivity, requirig intensive medical psychiatric care as well as the indefinite need for social and economic support. Here, we propose to apply a quantum-similarity approach to discover novel modulators (inhibitors) of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), aiming to elevate endocannabinoid tone to relieve the negative symptoms of schizophrenia.

Link to NIH RePORT